Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions at different rates across generations
Lana Meshnik, Dan Bar-Yaacov, Dana Kasztan, Tali Neiger, Tal Cohen, Mor Kishner, Itay Valenci, Sara Dadon, Christopher J. Klein, Jeffery M. Vance, Yoram Nevo, Stephan L. Zuchner, Dan Mishmar, Anat Ben‐Zvi
The paper shows that mutant mitofusin in C. elegans leads to differential removal of mtDNA deletions across generations, with smaller deletions being lost faster.
bioRxiv · Dec 23, 2020 · PreprintGenetics