Dan Mishmar

The paper identifies a conserved post-birth metabolic switch in vertebrates characterized by elevated mitochondrial and nuclear gene expression across multiple tissues.

The paper shows that mutant mitofusin in C. elegans leads to differential removal of mtDNA deletions across generations, with smaller deletions being lost faster.

The paper identifies two distinct subpopulations of pancreatic beta cells in humans and mice based on mitochondrial and nuclear gene expression, showing divergence in metabolic signatures.

The paper uses a split mDHFR PCA assay to assess how disease-causing mutations in OXPHOS complex I subunits affect their physical interactions.

The paper identifies a conserved DNase-I footprinting pattern across human mtDNA, suggesting a regulated protein-DNA organization involved in mtDNA transcription.

The paper examines co-expression of mitochondrial and nuclear OXPHOS genes across human tissues, finding positive co-expression in most tissues but negative correlation in ancient brain regions.

The paper uses deep sequencing to analyze mtDNA transcription in human and metazoan organisms, revealing conserved pausing sites and divergence across species.