Niels Kruse

This paper validates serum neurofilament light chain (NfL) as a biomarker for Parkinson's disease progression, showing increased levels in PD patients compared to healthy controls and a longitudinal increase correlating with clinical severity.

The paper uses machine learning to identify neurodegeneration signatures in non-human primates caused by patient-derived α-synuclein structures, showing that small aggregates are as toxic as larger fibrils.