Author

Leonard M. Milstone

Yale UniversityORCID 0000-0002-4038-4358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Julia OhiD· 3 shared Aaron Y. KohiD· 2 shared Elizabeth S. Aiken· 2 shared Morgan M. SeverniD· 2 shared Nan Guo RingiD· 2 shared Ryan CaldwelliD· 2 shared Wei Zhou· 2 shared Anita Yvonne VoigtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Julia OhORCID

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Author profile →

3 papers

Recent·Most cited

Species and strain diversity in Staphylococcus drive divergent host responses in human skin

Ruoyu Yang, Morgan M. Severn, Elizabeth S. Aiken, Wei Zhou, Anita Yvonne Voigt, Gabrielle Walker, Aaron Y. Koh, Minghao Gong, Maheshwor Thapa, Shuzhao Li, Leonard M. Milstone, Julia Oh

The paper profiles skin responses to 187 Staphylococcus strains across seven species in a human skin model, revealing strain-level diversity in host immune and barrier responses.

bioRxiv · Apr 30, 2026 · PreprintMicrobiology

Population genomics of skin Staphylococcus reveals disease-associated restructuring of species and strain diversity

Wei Zhou, Aaron Y. Koh, Morgan M. Severn, Elizabeth S. Aiken, Ryan Caldwell, Zoe Scholar, Nan Guo Ring, Leonard M. Milstone, Julia Oh

This study sequenced 2,920 skin Staphylococcus isolates to show disease selects species-level traits while reshaping strain populations and their functional diversity within hosts.

bioRxiv · Apr 29, 2026 · PreprintMicrobiology

Genotype-environment-driven dysbiosis in the skin microbiome of ichthyosis

Wei Lan Zhou, Nan Guo Ring, Ryan Caldwell, Leonard M. Milstone, Julia Oh

This study shows that ichthyosis genotype, phenotype, and host factors influence the skin microbiome's species, strain, and metabolic pathway composition.

Journal of Investigative Dermatology · Jun 25, 2025Peer-reviewedMicrobiology