James M. Parkin

This paper designs a synthetic cell-cell signaling circuit that enables long-distance communication through active AHL pulse propagation in bacterial consortia.

The paper investigates how cell-cell communication circuits operate in a heterogeneous environment, finding that signal diffusion and colony placement affect communication range and speed.

The paper designs a pulsatile communication circuit in bacteria to enable dynamic patterning and long-distance communication through model-driven optimization of promoter and RBS strengths.