Genetic & Genomic MedicinemedRxivPreprint
β1- and β2-adrenergic Receptor Haplotypes Regulate Therapeutic Responses to Placebo and the Biased Ligand β-blocker Bucindolol
Ian A. Carroll, Dobromir B. Slavov, Eric R. Jonas…·Michael R. Bristow
This paper shows that β1- and β2-adrenergic receptor haplotypes influence responses to bucindolol and placebo in heart failure patients, with internalizing haplotypes providing protection and bucindolol being effective in internalization-resistant ones.
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