This paper shows that β1- and β2-adrenergic receptor haplotypes influence responses to bucindolol and placebo in heart failure patients, with internalizing haplotypes providing protection and bucindolol being effective in internalization-resistant ones.

medRxiv · Aug 22, 2025 · PreprintGenetic & Genomic Medicine

Synergistic Notch-WNT Activation Underlies Pediatric Dilated Cardiomyopathy

Obed Ofori Nyarko, Ethan Rausch, Jared R.H. Goff, Anis Karimpour‐Fard, Caitlyn S. Conard, Laura Hernandez‐Lagunas, McKenna P.A. Burns, Michael R. Bristow, Joseph C. Cleveland, Matthew L. Stone, Brisa Peña, Shelley D. Miyamoto, Brian L. Stauffer, Carmen C. Sucharov

This study identifies synergistic Notch-WNT signaling activation in pediatric dilated cardiomyopathy and shows its inhibition improves cardiac function.

bioRxiv · Jun 7, 2025 · PreprintMolecular Biology

Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure

Thomas G. Martin, Dakota R. Hunt, Christopher C. Ebmeier, Abhishek P. Dhand, Christina Alamana, Joseph C. Cleveland, Sharon Louise Graw, Sarah Bruner, Michael R. Bristow, Luisa Mestroni, Matthew R.G. Taylor, Jason A. Burdick, Amrut V. Ambardekar, Peter M. Buttrick, Leslie Anne Leinwand

The paper identifies CaMKIIδ-B subcellular localization as a determinant of myocardial recovery in heart failure, showing cytoplasmic retention impairs recovery.

bioRxiv · May 16, 2025 · PreprintPhysiology