Joshua L. Cherry

A bistable type III secretion system is primed and loaded in Pseudomonas aeruginosa hypervirulent isolates with positively selected codon changes in exsA or exsD

The paper identifies positively selected codon changes in exsA or exsD that hyperactivate the T3SS in P. aeruginosa, leading to hypervirulence through increased T3SS activity and immunopathology.

Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

The paper argues that heterozygote advantage cannot explain MHC diversity and that MHC diversity may instead explain heterozygote advantage.

GnT motifs: short nucleotide tracts of >=8bp that can increase T:A->G:C mutation rates >1000-fold in bacteria

The paper identifies GnT motifs, short nucleotide tracts that significantly increase T:A->G:C mutation rates in bacteria through experimental and bioinformatic analysis.

T Residues Preceded by Runs of G are Hotspots of T to G Mutation in Bacteria

The paper identifies that runs of three or more G residues preceding a T increase T to G mutation rates in bacteria, with stronger effects on the leading strand.

Extreme C-to-A Hypermutation at a Site of Cytosine-N4 Methylation

The paper reports that a Salmonella restriction-modification system causes extreme C-to-A hypermutation at N4-methylated cytosines, increasing mutation rates by ~500-fold compared to normal.