Targeting Mesothelin via the native T cell receptor
Kiriakos Koukoulias, Ryu Yanagisawa, Alejandro G. Torres Chavez, Penelope Georgia Papayanni, Yovana Velazquez, Spyridoula Vasileiou, Ann Marie Leen
The paper demonstrates that T cells from 72% of individuals mount a specific response against Mesothelin, showing cytotoxicity and anti-tumor effects in 3D models.
bioRxiv · Dec 3, 2025 · PreprintCell Biology