Author

Ann Marie Leen

Baylor College of MedicineORCID 0000-0002-4470-1760Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro G. Torres ChaveziD· 2 shared Anmol Gupta· 1 shared Juan F. VeraiD· 1 shared Kiriakos KoukouliasiD· 1 shared Mary Kathryn McKennaiD· 1 shared Neha Daga· 1 shared Penelope Georgia PapayanniiD· 1 shared Pradip BajgainiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Alejandro G. Torres ChavezORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintDec 3, 2025

Targeting Mesothelin via the native T cell receptor

Kiriakos Koukoulias, Ryu Yanagisawa, Alejandro G. Torres Chavez…·Ann Marie Leen

The paper demonstrates that T cells from 72% of individuals mount a specific response against Mesothelin, showing cytotoxicity and anti-tumor effects in 3D models.

DOI 10.64898/2025.12.02.689353

humanexperimental assay

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ImmunologyFrontiers in ImmunologyPeer-reviewedJul 30, 2025

IL-7 armed binary CAR T cell strategy to augment potency against solid tumors

Alejandro G. Torres Chavez, Mary Kathryn McKenna, Anmol Gupta…·Pradip Bajgain

This study develops a binary CAR T cell strategy targeting PSCA and MUC1 with IL-7 expression to improve antitumor potency and persistence in pancreatic tumors.

11 citationstop 4%

mouseCITE-seq

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