Interleaved intersectional strategy enables genetic lineage tracing with enhanced specificity
Maoying Han, Zhicong Liu, Xiuzhen Huang, Lei Liu, bo zhou, Kathy O. Lui, Qiang Shu, Bin Zhou
The paper introduces an interleaved intersectional reporter (IIR) strategy to improve genetic lineage tracing specificity by combining inducible CreER with constitutively active Dre, enabling precise tracking and functional analysis of cardiac fibroblasts.
bioRxiv · Mar 6, 2024 · PreprintGenetics