Kathy O. Lui

This paper introduces two new Cre systems, roxCre and loxCre, for improved conditional gene targeting and lineage tracing in vivo.

The paper introduces an interleaved intersectional reporter (IIR) strategy to improve genetic lineage tracing specificity by combining inducible CreER with constitutively active Dre, enabling precise tracking and functional analysis of cardiac fibroblasts.

This study shows that regulatory T-cells are essential for neonatal heart regeneration, as their depletion impairs cardiac repair and increases fibrosis.