A motif preferred adenine base editor with minimal bystander and off-targets editing
Mengyu Shang, Yinuo Li, Qiuyu Cao, Jingxuan Ren, Yuqiang Zeng, Jinxin Wang, Rachel V. L. Gonzalez, Xiaohui Zhang
This paper develops ABE10, an improved adenine base editor with enhanced A-to-G editing efficiency and reduced off-target effects, demonstrating its utility in disease modeling and gene therapy.
Nature Communications · Oct 15, 2025Peer-reviewedMolecular Biology