Author

Mengyu Shang

Chinese Academy of Medical Sciences & Peking Union Medical College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Jingxuan ReniD· 1 shared Jinxin WangiD· 1 shared Kai WuiD· 1 shared Mengkai ZhangiD· 1 shared Qiuyu Cao· 1 shared Rachel V. L. Gonzalez· 1 shared Shang WangiD· 1 shared Weiren HuangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Jingxuan RenORCID

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2 papers

Recent·Most cited

Splicing-guaranteed artificial introns enable efficient homology-directed repair at internal exons and streamlined cell engineering

Shang Wang, Xianteng Wang, Mengyu Shang, Kai Wu, Mengkai Zhang, Weiren Huang

This paper introduces ARI-HDR, a method for efficient internal-exon editing using splicing-guaranteed artificial introns, achieving over 80% editing efficiency in human genes.

bioRxiv · Oct 16, 2026 · PreprintMolecular Biology

A motif preferred adenine base editor with minimal bystander and off-targets editing

Mengyu Shang, Yinuo Li, Qiuyu Cao, Jingxuan Ren, Yuqiang Zeng, Jinxin Wang, Rachel V. L. Gonzalez, Xiaohui Zhang

This paper develops ABE10, an improved adenine base editor with enhanced A-to-G editing efficiency and reduced off-target effects, demonstrating its utility in disease modeling and gene therapy.

Nature Communications · Oct 15, 2025Peer-reviewedMolecular Biology