Convergent Roles of Growth Differentiation Factor-15 (GDF-15) in Mechanotransduction, Vascular Disorganization, and Immune Suppression in Melanoma
Yu‐Chi Chen, Vishnu Sravan Bollu, Sina Kheirabadi, Kyle Brian LaPenna, Arthur S Berg, Pingnian He, Todd D. Schell, Amir Sheikhi, Erdem D. Tabdanov, Gavin P. Robertson
This study identifies GDF-15 as a mechanosensing-regulated driver of melanoma pathogenesis, linking mechanical stress, vascular disorganization, and immune suppression.
bioRxiv · Jan 15, 2026 · PreprintCancer Biology