Author

Negar Golestani

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4112-7601Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ariela Buxbaum Grice· 2 shared Eli KritzeriD· 2 shared Alan Edward RentoniD· 1 shared Alexander William Charney· 1 shared Alison GoateiD· 1 shared Alzheimer’s Disease Neuroimaging Initiative· 1 shared Anina Lund· 1 shared Anina N. LundiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Ariela Buxbaum Grice

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Author profile →

2 papers

Recent·Most cited

Surrogate variables and the risk of overfitting in neuropsychiatric gene expression analyses

Dung Hoang, Ryan Thompson, Anina Lund, Eli Kritzer, Ariela Buxbaum Grice, Divya John, Girish Nadkarni, Negar Golestani, Alexander William Charney, Noam Beckmann

This study shows that surrogate variable analysis (SVA) can lead to overfitting and reduced cross-cohort reproducibility in neuropsychiatric gene expression analyses.

bioRxiv · Oct 12, 2026 · PreprintBioinformatics

Genetic Associations with Temporal Modeling of Alzheimer's Disease Progression Supports a Novel Paradigm for Disease Risk

Daniel M. Jordan, Eli Kritzer, Ryan C. Thompson, Anina N. Lund, Tulsi Patel, Ariela Buxbaum Grice, D John, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Neuroimaging Initiative, Alison Goate, Benjamin Scott Glicksberg, Negar Golestani, Maria Koromina, Alan Edward Renton, Noam D. Beckmann

This paper uses temporal modeling of Alzheimer's disease progression with metabolomics data to identify novel genetic loci associated with disease speed, independent of traditional case-control associations.

medRxiv · Jul 10, 2026 · PreprintGenetic & Genomic Medicine