Alan Edward Renton

This paper uses temporal modeling of Alzheimer's disease progression with metabolomics data to identify novel genetic loci associated with disease speed, independent of traditional case-control associations.

This paper constructs a genomic-informed dementia risk score combining genetic and clinical factors and finds that most memory clinic patients have at least one high-risk indicator, with higher burden linked to increased dementia risk.

This study examines how telomere length, epigenetic age, and mitochondrial DNA abundance interact in Alzheimer's Disease, finding that their combination affects grey-matter volume.

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

The paper identifies three H1 sub-haplotypes at the 17q21.31 locus associated with Parkinson's disease risk and links them to LRRC37A/2 expression in astrocytes.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

This study examines the effect of APOE genotypes and polygenic risk scores on dementia and cognitive decline in a longitudinal cohort of healthy older individuals, finding increased risks for APOE ε4 carriers and high PRS tertiles.

This study integrates Alzheimer’s disease GWAS with myeloid epigenomic data to identify risk enhancers and causal genes, implicating myeloid endolysosomal dysfunction in AD pathogenesis.

The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.