R-loops and Topoisomerase 1 facilitate formation of transcriptional DSBs at gene bodies of hypertranscribed genes
Osama Hidmi, Sara K. Oster, Jonathan Monin, Rami I. Aqeilan
The paper investigates the role of R-loops and Topoisomerase 1 in forming transcriptional DSBs at hypertranscribed genes and links these breaks to cancer development.
bioRxiv · Dec 12, 2022 · PreprintMolecular Biology