Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling
Jiali Chen, Qinghe Zeng, Xu Wang, Rui Cheng Xu, Weidong Wang, Yuliang Huang, Qi Sun, Wenhua Yuan, Pinger Wang, Di Chen, Peijian Tong, Hongting Jin
The paper identifies aberrant DNA methylation and TNXB expression in hemophilic arthropathy, showing their role in cartilage degradation via AKT signaling.
eLife · May 31, 2024Peer-reviewedMolecular Biology