Di Chen

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

The paper identifies aberrant DNA methylation and TNXB expression in hemophilic arthropathy, showing their role in cartilage degradation via AKT signaling.

Multiple Cullin-Associated E3 Ligases Regulate Cyclin D1 Protein Stability

This study identifies multiple cullin-associated E3 ligases that regulate cyclin D1 protein stability through ubiquitination and proteasome degradation, affecting cell cycle progression and proliferation.

Specific Deletion of Axin1 Leads to Activation of β-Catenin/BMP Signaling Resulting in Fibular Hemimelia Phenotype in Mice

This study shows that Axin1 deletion in mice causes fibular hemimelia by disrupting β-catenin and BMP signaling during limb development.

Focal adhesion protein vinculin inhibits Mef2c-driven sclerostin expression in osteocytes to promote bone formation in mice

This study shows that vinculin inhibits Mef2c-driven sclerostin expression in osteocytes, promoting bone formation in mice by enhancing estrogen regulation.