Xu Wang

Proximity Labelling Reveals Spatial Organisation of Mitochondrial Protein Import Complexes

The paper uses proximity labeling to identify proteins interacting with mitochondrial import complexes, revealing EXD2 as a TOM/SAM-associated factor at the mitochondrial outer membrane.

Protein Language Models Encode Evolutionary Grammar but Conflate Topological and Thermodynamic Phases

This paper shows that protein language models like ESM-2 encode evolutionary grammar rather than three-dimensional geometry, conflate topological and thermodynamic phases, and require explicit physical constraints for accurate modeling.

HPV16 recruitment of SMARCAL1 to viral and host replication forks is required for the viral life cycle

This paper shows that HPV16 requires SMARCAL1 to recruit to viral and host replication forks, which is essential for its life cycle and prevents DNA damage and genome integration.

The Utility of Fibroblast Co-culture for the Maintenance of Episomes in Human Papillomavirus-Associated Cancer Models

The paper shows that HPV16+ OPC cell lines lose episomal status in monoculture and proposes fibroblast co-culture to maintain episomal viral genomes.

Epigenetic activation of CHST2 by promoter hypomethylation promotes progression of triple-negative breast cancer

This study identifies CHST2 as an epigenetically activated gene in TNBC that promotes invasion and poor prognosis through promoter hypomethylation and sulfotransferase activity.

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 Function

This study identifies novel host factors interacting with HPV16 E2 during differentiation using proximity proteomics, revealing a cooperative E2-TOPBP1-NCL axis critical for viral genome stability.

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

The paper identifies aberrant DNA methylation and TNXB expression in hemophilic arthropathy, showing their role in cartilage degradation via AKT signaling.

Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease

The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.