Proteomic and Metabolomic Profiling Nominates Druggable Targets and Biomarkers forPulmonary Arterial Hypertension-Associated Myopathy and Exercise Intolerance
Phablo Abreu, Ryan A. Moon, Jenna B. Mendelson, Todd W. Markowski, LeeAnn Higgins, Kevin J. Murray, Candace R. Guerrero, Jeffrey C. Blake, Sasha Z. Prisco, Kurt W. Prins
The paper identifies differential metabolic and proteomic changes in skeletal muscles of PAH rats and suggests mitochondrial biogenesis and proteasome activation as potential therapeutic targets.
bioRxiv · Mar 27, 2025 · PreprintSystems Biology