LeeAnn Higgins

This study identifies HNF-1β's role in recruiting the NuRD complex to activate gene transcription through chromatin remodeling and acetylation.

This paper develops a low-input prenylomic workflow to enable cell-type-specific analysis of prenylated proteins in mouse liver tissue.

This study identifies acetylated PLIN2 as a critical mediator of inflammation by facilitating oxylipin synthesis on lipid droplets through interactions with inflammatory proteins.

This study uses multi-omic profiling to identify renal mechanisms in PAH, revealing structural and metabolic changes and potential therapeutic targets.

The paper uses proteomics to compare alterations in the right atrium and right ventricle of pigs with right heart failure, identifying shared and distinct metabolic changes.

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

This study uses multi-omics profiling to identify molecular mechanisms contributing to progressive right ventricular dysfunction in pigs.

The paper examines mRNA and protein expression of insulin receptor isoforms in breast cancer cell lines and finds that IR-A is overexpressed compared to IR-B, with IR-A protein expression demonstrated for the first time.

The paper identifies differential metabolic and proteomic changes in skeletal muscles of PAH rats and suggests mitochondrial biogenesis and proteasome activation as potential therapeutic targets.

This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.

This study develops a Notch inhibitory nanobody and demonstrates a strategy to enhance its efficacy through fusion with an Aerolysin domain.

SC144 improves right ventricular function in pulmonary artery banded pigs by reducing inflammation, restoring metabolism, and enhancing cell communication.

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.