Kevin J. Murray

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

The paper examines mRNA and protein expression of insulin receptor isoforms in breast cancer cell lines and finds that IR-A is overexpressed compared to IR-B, with IR-A protein expression demonstrated for the first time.

The paper identifies differential metabolic and proteomic changes in skeletal muscles of PAH rats and suggests mitochondrial biogenesis and proteasome activation as potential therapeutic targets.

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.