Todd W. Markowski

This study identifies HNF-1β's role in recruiting the NuRD complex to activate gene transcription through chromatin remodeling and acetylation.

This study shows that impaired BCAA metabolism promotes ferroptosis, leading to pulmonary arterial hypertension and associated liver disease, and that targeting BCAA metabolism can alleviate these effects.

This study uses multi-omics profiling to identify molecular mechanisms contributing to progressive right ventricular dysfunction in pigs.

The paper examines mRNA and protein expression of insulin receptor isoforms in breast cancer cell lines and finds that IR-A is overexpressed compared to IR-B, with IR-A protein expression demonstrated for the first time.

The paper identifies differential metabolic and proteomic changes in skeletal muscles of PAH rats and suggests mitochondrial biogenesis and proteasome activation as potential therapeutic targets.

This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.

SC144 improves right ventricular function in pulmonary artery banded pigs by reducing inflammation, restoring metabolism, and enhancing cell communication.