Coupling lysosomal polarity and purinergic signaling regulates B cell activation
Martina Alamo, Juan Pablo Bozo, Isidora Riobó, Tamara López-López, Johan M. Kux, Michelle Y. Jaeckstein, Björn Rissiek, Jöerg Heeren, Daniela Sauma, Pablo José Sáez, María-Isabel Yuseff
This study shows ATP enhances B cell function by promoting antigen extraction and presentation through P2RX4 trafficking and lysosomal polarity.
bioRxiv · Sep 21, 2026 · PreprintImmunology