Pablo José Sáez

This study shows ATP enhances B cell function by promoting antigen extraction and presentation through P2RX4 trafficking and lysosomal polarity.

Carbenoxolone blocks cell migration by inhibiting SERCA, causing ER Ca2+ leak and disrupting intracellular Ca2+ homeostasis.

The paper develops a theoretical model and experimental analysis to study how branched cells balance shape dynamics for directional decision-making during migration.

This study identifies distinct chemotactic strategies in neutrophils and dendritic cells, showing how cytoskeletal components and environmental factors influence directed migration in complex tissues.

The paper identifies norepinephrine as a trigger of macrophage efferocytosis in brown adipose tissue, linking sympathetic signaling to metabolic adaptation through β2-adrenergic and Axl/Mertk pathways.

This study identifies SPARC as a driver of early breast tumor progression through a TGF-β-dependent mechanism, showing its correlation with MT1-MMP and invasiveness.

This study identifies podocyte exopher-formation as a novel mechanism for removing antigen/autoantibody aggregates in membranous nephropathy, with potential for non-invasive monitoring.

This study shows that lateral confinement controls pericyte shape and migration, with dry friction theory accurately predicting their behavior in vitro.