Jöerg Heeren

This study shows ATP enhances B cell function by promoting antigen extraction and presentation through P2RX4 trafficking and lysosomal polarity.

This paper isolates and cultures endothelial cells from brown and white adipose tissue, showing that brown adipose tissue endothelial cells lose their identity in culture and adopt features of white adipose and lymphatic endothelial cells.

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.

The paper identifies norepinephrine as a trigger of macrophage efferocytosis in brown adipose tissue, linking sympathetic signaling to metabolic adaptation through β2-adrenergic and Axl/Mertk pathways.

Shiny-Calorie provides a flexible, open-source tool for analyzing and visualizing indirect calorimetry data, supporting standardized integration and statistical analysis of metabolic phenotyping datasets.

This study uses snRNA-seq to analyze cold-induced changes in brown adipocyte subtypes in mice, identifying ChREBP's role in lipogenic adipocyte identity and plasticity.

This study uses infrared laser sampling combined with shotgun lipidomics to identify lipid markers in palatine tonsil carcinoma, showing consistent differences between tumor and healthy tissue.

This study shows that ADAM10's non-catalytic function, not its enzymatic activity, regulates hepatic progenitor cell fate and liver regeneration.

This study shows that hepatic VPS35 deficiency disrupts lysosomal cholesterol metabolism, leading to increased cholesterol levels in plasma and liver.

This study shows apoE4 disrupts sortilin's role in neuronal lipid metabolism and endocannabinoid signaling, contributing to Alzheimer's disease risk.