Bipolar Switching by HCN Voltage Sensor Underlies Hyperpolarization Activation.
John B. Cowgill, Vadim A. Klenchin, Claudia P. Alvarez-Baron, Debanjan Tewari, Alexander Blair, Baron Chanda
The paper identifies how the HCN voltage sensor can drive pore opening in either direction, revealing a common principle in voltage-gated ion channels.
Proceedings of the National Academy of Sciences · Dec 26, 2018Peer-reviewedNeuroscience