Author

Vadim A. Klenchin

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2

Frequent Co-Authors

Brandon F. KeeleiD· 2 shared Christine M. FennesseyiD· 2 shared David T. EvansiD· 2 shared Guangping GaoiD· 2 shared Mario RoedereriD· 2 shared Matthew R. GardneriD· 2 shared Natasha M. ClarkiD· 2 shared Nida K. Keles· 2 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Brandon F. KeeleORCID

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3 papers

Recent·Most cited

Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies

Natasha M. Clark, Nida K. Keles, Grace N. Hagedorn, Vadim A. Klenchin, Hanné Andersen, Jim Treece, Christine M. Fennessey, Jun Xie, Thomas N. Denny, C. Todd DeMarco, Jose S Hernandez, Saverio Capuano, Matthew R. Gardner, Brandon F. Keele, Guangping Gao, , David T. Evans

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

bioRxiv · Apr 23, 2026 · PreprintImmunology

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Vadim A. Klenchin, Natasha M. Clark, Nida K. Keles, Saverio Capuano, Rosemarie D. Mason, Guangping Gao, Aimee Teo Broman, Emek Köse, Taina T. Immonen, Christine M. Fennessey, Brandon F. Keele, Jeffrey D. Lifson, Mario Roederer, Matthew R. Gardner, David T. Evans

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

Science Immunology · Feb 28, 2025Peer-reviewedImmunology

Bipolar Switching by HCN Voltage Sensor Underlies Hyperpolarization Activation.

John B. Cowgill, Vadim A. Klenchin, Claudia P. Alvarez-Baron, Debanjan Tewari, Alexander Blair, Baron Chanda

The paper identifies how the HCN voltage sensor can drive pore opening in either direction, revealing a common principle in voltage-gated ion channels.

Proceedings of the National Academy of Sciences · Dec 26, 2018Peer-reviewedNeuroscience