Baron Chanda

This study shows lipid bilayers enable cooperative cAMP binding to HCN channels but do not affect intrinsic binding affinity, revealing a role for membranes in enhancing inter-subunit interactions.

This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.

This paper introduces DeFrNDs, detergent-free nanodiscs made with engineered membrane scaffold peptides, enabling high-resolution structural analysis of membrane proteins in native lipid environments.

The paper identifies how the HCN voltage sensor can drive pore opening in either direction, revealing a common principle in voltage-gated ion channels.