Sebastian James Crutch

Incomplete letter recognition is limited by cortical and not optical factors: Simulating the visual deficits of dementia in healthy adults

This study simulates visual deficits in healthy adults to determine if incomplete letter recognition issues in dementia patients are due to cortical or optical factors, finding cortical factors are more significant.

Graded multidimensional clinical and radiological variation in patients with Alzheimer's disease and posterior cortical atrophy

This study identifies graded multidimensional variations in cognition and brain volumes between Alzheimer's disease and posterior cortical atrophy, suggesting shared phenotypic continua rather than distinct categories.

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

This paper introduces SuStaIn, a machine learning method that identifies disease subtypes and their temporal progression from cross-sectional data, improving prediction of diagnostic conversion in neurodegenerative diseases.

Non-Parametric Mixture Modelling and its Application to Disease Progression Modelling

This paper introduces KDEMM for disease progression modeling, showing it outperforms GMMs in simulating cognitive data and aligns better with clinical phenotypes in Alzheimer's subtypes.