Environmental and mutational modulation of collateral fitness effects informs their mechanisms
Cameron Goff, Erh-Yeh Tsou, Jacob D. Mehlhoff, Marc Ostermeier
The paper measures how environmental and mutational factors influence collateral fitness effects in TEM-1 β-lactamase, finding that reducing aggregation or stabilizing the protein can mitigate deleterious effects.
Molecular Biology and Evolution · Apr 18, 2026Peer-reviewedEvolutionary Biology