Author

Marc Ostermeier

Johns Hopkins UniversityORCID 0000-0003-0900-3665Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

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Cameron GoffiD· 1 shared Erh-Yeh TsouiD· 1 shared Jacob D. MehlhoffiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperEvolutionary Biology

Cameron GoffORCID

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1 paper

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Evolutionary BiologyMolecular Biology and EvolutionPeer-reviewedApr 18, 2026

Environmental and mutational modulation of collateral fitness effects informs their mechanisms

Cameron Goff, Erh-Yeh Tsou, Jacob D. Mehlhoff, Marc Ostermeier

The paper measures how environmental and mutational factors influence collateral fitness effects in TEM-1 β-lactamase, finding that reducing aggregation or stabilizing the protein can mitigate deleterious effects.

DOI 10.1093/molbev/msag106

protein structureexperimental assay

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