Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones
Erik Koppes, Marie A. Johnson, James J. Moresco, Patrizia Luppi, Dale W. Lewis, Donna Beer Stolz, Jolene K. Diedrich, John R. Yates, Ronald C. Wek, Simon C. Watkins, Susanne M. Gollin, Hyun Jung Park, Peter F. Drain, Robert D. Nicholls
This study identifies a reduction in ER chaperones in PWS β-cells, leading to impaired insulin secretion and ER stress.
PLoS Genetics · Apr 17, 2023Peer-reviewedGenetics