Author

Ronald C. Wek

Indiana University IndianapolisORCID 0000-0002-2087-5504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Microbiology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Amber L. MosleyiD· 1 shared Avery M. RunnebohmiD· 1 shared Dale W. Lewis· 1 shared Donna Beer StolziD· 1 shared Emma H. DoudiD· 1 shared Erik KoppesiD· 1 shared H. R. Sagara WijeratneiD· 1 shared Hyun Jung ParkiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSystems Biology

Amber L. MosleyORCID

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4 papers

Recent·Most cited

Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response

Kirk A. Staschke, Nicholas T. Walda, Lucciano A. Pearce, Ronald C. Wek, Wen Zhu, Yuichiro Takagi

The paper describes how ASX-173 inhibits asparagine synthetase, induces the integrated stress response, and reduces cell growth in HEK-293A cells.

bioRxiv · Oct 16, 2025 · PreprintMolecular Biology

Application of Whole Proteome Thermal Shift Assays to Define PERK-dependent Changes in Protein Homeostasis during the Unfolded Protein Response

Neil A. McCracken, Sarah A. Peck Justice, Whitney R. Smith-Kinnaman, H. R. Sagara Wijeratne, Avery M. Runnebohm, S. William Pelletier, Emma H. Doud, Ronald C. Wek, Amber L. Mosley

The paper uses proteomics and PISA analysis to study PERK-dependent changes in protein homeostasis during ER stress induced by tunicamycin.

bioRxiv · Apr 8, 2025 · PreprintSystems Biology

Cap-independent translation directs stress-induced differentiation of the protozoan parasite Toxoplasma gondii

Vishakha Dey, Michael J. Holmes, Matheus Silva e Bastos, Ronald C. Wek, William J. Sullivan

This study identifies cap-independent translation as a mechanism driving stress-induced differentiation in Toxoplasma gondii by regulating BFD1 protein synthesis.

Journal of Biological Chemistry · Nov 13, 2024Peer-reviewedMicrobiology

Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones

Erik Koppes, Marie A. Johnson, James J. Moresco, Patrizia Luppi, Dale W. Lewis, Donna Beer Stolz, Jolene K. Diedrich, John R. Yates, Ronald C. Wek, Simon C. Watkins, Susanne M. Gollin, Hyun Jung Park, Peter F. Drain, Robert D. Nicholls

This study identifies a reduction in ER chaperones in PWS β-cells, leading to impaired insulin secretion and ER stress.

PLoS Genetics · Apr 17, 2023Peer-reviewedGenetics