James J. Moresco

The paper reports cryo-EM structures of cardiac AL amyloid fibrils from IGLV6 light chains, revealing conserved structural motifs and sequence-dependent folding mechanisms.

This study identifies the Rab32-LRMDA-Retriever complex as essential for endolysosomal trafficking in innate immune cells, maintaining intestinal immune homeostasis.

This study identifies a reduction in ER chaperones in PWS β-cells, leading to impaired insulin secretion and ER stress.

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

This study shows Rvb1/Rvb2 proteins link transcription and translation during glucose starvation by sequestering mRNAs into granules and modulating their translatability.

The paper identifies SNPC-1.3 as a male-specific transcription factor that regulates piRNA expression in C. elegans and shows its sex-specific regulation by TRA-1.

This study shows that PIR-1 dephosphorylates ppp-RNAs and is essential for 26G-RNA maturation and regulation of gene expression in C. elegans.

The paper identifies trans regulators of ADAR1 and ADAR2 using BioID and mass-spectrometry, validating novel interactors as RNA editing regulators.

This study identifies tick saliva proteins injected during feeding using LC-MS/MS, finding 284 conserved proteins that may serve as vaccine targets.

The paper identifies five novel genes required for RNAi-mediated transposon suppression in C. neoformans, revealing a non-Dicer RNase III and nucleolar factors involved in endo-siRNA biogenesis.

TargetSeeker-MS identifies drug targets on a proteome scale using EBPS-MS data, showing reproducibility in C. elegans and HEK293 samples treated with benomyl.

This study shows CCDC11 is essential for cytokinesis and cell-cell adhesion via RhoA regulation, linking it to heterotaxy disease pathogenesis.

The paper identifies CBD-1 as a scaffold protein in C. elegans that forms two distinct complexes for vitelline layer assembly and egg activation, revealing its multifaceted role in eggshell formation and fertilization.

The paper shows that MET-2/SETDB1 and its interactors LIN-65/ATF7IP and ARLE-14/ARL14EP regulate the timing of heterochromatin formation during C. elegans embryogenesis.

The paper develops a method to profile spliceosome-bound RNA at nucleotide resolution in yeast, revealing non-canonical splicing events and substrate features influencing catalytic efficiency.