Molecular BiologybioRxivPreprint
Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors
Emeric J. Charles, Ross White, Ryan V. Tran…·Jason D. Fernandes
This paper introduces ELXRs, CRISPR-CasX-based epigenetic repressors that use sequential proofreading to enhance specificity and potency by reading chromatin state before DNA methylation.
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