Author

Christopher Duncan-Lewis

University of California, BerkeleyORCID 0000-0001-7775-5856Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Amanda MokiD· 1 shared Anna MrakiD· 1 shared Ashley T WongiD· 1 shared Beatriz AlvaradoiD· 1 shared Benjamin L. Oakes· 1 shared Britt A. GlaunsingeriD· 1 shared Carlos SantamaríaiD· 1 shared Christie C. SzeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Amanda MokORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 31, 2026

Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors

Emeric J. Charles, Ross White, Ryan V. Tran…·Jason D. Fernandes

This paper introduces ELXRs, CRISPR-CasX-based epigenetic repressors that use sequential proofreading to enhance specificity and potency by reading chromatin state before DNA methylation.

1 citation

mouseCRISPR screen

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Molecular BiologyeLifePeer-reviewedJun 4, 2021

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

Christopher Duncan-Lewis, Ella Hartenian, Valeria M. King, Britt A. Glaunsinger

The paper shows that mRNA decay during early apoptosis represses RNA polymerase II transcription, creating positive feedback that amplifies gene expression shutdown.

29 citations

humanmultiome

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