Author

Elena M. Smekalova

Beam Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amanda MokiD· 1 shared Anna MrakiD· 1 shared Anuj KumariD· 1 shared Ashley T WongiD· 1 shared Barbara TestoniiD· 1 shared Beatriz AlvaradoiD· 1 shared Benjamin L. Oakes· 1 shared Carlos SantamaríaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Amanda MokORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 31, 2026

Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors

Emeric J. Charles, Ross White, Ryan V. Tran…·Jason D. Fernandes

This paper introduces ELXRs, CRISPR-CasX-based epigenetic repressors that use sequential proofreading to enhance specificity and potency by reading chromatin state before DNA methylation.

1 citation

mouseCRISPR screen

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Molecular BiologybioRxivPreprintFeb 6, 2026

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

Anuj Kumar, Emmanuel Combe, Elena M. Smekalova…·Fabien Zoulim

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

DOI 10.64898/2026.02.06.704371

humanexperimental assay

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