An integrated view of the structure and function of the human 4D nucleome
Job Dekker, Betül Akgöl Oksuz, Yang Zhang, Ye Wang, Miriam K. Minsk, Shuzhen Kuang, Liyan Yang, Johan Harmen Gibcus, Nils Krietenstein, Oliver J. Rando, Jie Xu, Derek H. Janssens, Steven Henikoff, Alexander Kukalev, Andréa Willemin, , Feng Yue
The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.
Nature · Dec 17, 2025Peer-reviewedGenomics