Oliver J. Rando

This study shows that H2B ubiquitylation inhibits H2A.Z deposition by SWR1C and is required for H2A.Z re-localization during replication stress.

The paper adapts REMORA to study RNA-binding protein functions in early mouse embryos, identifying direct regulatory roles for several RBPs, including Alyref in 3' polyadenylation control.

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

This study benchmarks the OTTR protocol for characterizing tRNAs and tRNA fragments in yeast and mouse, showing its accuracy and revealing new insights into sperm small RNA content.

This study creates a single-cell RNA-seq atlas of the mouse seminal vesicle, identifying secretory and immune cell populations and their transcriptomes.

This study investigates enhancer-promoter contact architecture and communication, finding that RNA polymerase II and PARP1 activity stabilize these contacts.

The paper shows that Cre recombinase can be transported from somatic tissues to the male reproductive tract in mice, suggesting inter-tissue RNA or protein trafficking.

The paper reanalyzes sperm chromatin structure in mice, finding that prior studies were contaminated by cell-free chromatin, and identifies open loci associated with early development.

This study evaluates 3C-based assays to understand how experimental parameters affect chromatin interaction detection and quantification, leading to the development of Hi-C 3.0.

This study shows that Rlim is essential for spermiogenesis in male mice, as its deletion leads to defective sperm production and fertility issues.

The paper creates a single-cell atlas of the murine epididymis and vas deferens, identifying cell types and their regional specialization, and revealing potential signaling networks.

The paper investigates how transcriptional regulatory elements influence the 3D organization of microTADs in mouse stem cells.

This study improves chromosome architecture mapping by using Micro-C to achieve nucleosome-resolution insights in human cells, revealing new looping interactions and structural patterns.

The paper examines how different fertilization methods affect preimplantation gene regulation in mouse embryos, identifying stable and flexible gene expression patterns and the role of sperm RNAs in development.

The paper examines cytosine methylation changes in sperm during post-testicular maturation and finds minimal changes, with an unexpected extracellular DNA contamination in caput epididymal sperm.

The paper develops a method to profile TF-DNA interactions in single cells and embryos, showing NANOG's greater reliance on BRG1 in vivo.

This study shows that removing tRNA genes from a chromosome does not broadly disrupt chromosome folding but affects local nucleosome positioning and SMC protein binding, as well as centromere and heterochromatin clustering.

This study identifies condensin-mediated chromatin condensation as a mechanism repressing transcription during quiescence in yeast and human cells.

The paper shows that tRF-GG regulates noncoding RNA production and histone levels, affecting MERVL element repression through U7 snRNA and RNA-binding proteins.

The paper shows that paternal social status in mice reversibly affects offspring growth and liver transcription through non-genetic cues, modulated by maternal experience.

This study shows that small RNAs acquired by sperm in the epididymis are critical for embryonic development in mice, as their absence leads to developmental failure and can be rescued by adding these RNAs.

The paper shows that small RNAs in mature mammalian sperm originate from epididymal somatic cells, not testicular germ cells, and are delivered via vesicular transport during post-testicular maturation.

The paper shows that larval density affects gene expression in C. elegans L1 larvae, identifies a density-dependent gene, and suggests a soluble signaling molecule mediates density sensing.

The paper uses ribosome profiling and RNA-Seq in budding yeast to analyze the translational effects of tRNA modifications, identifying new roles in gene regulation and retroelement control.

The paper introduces a synthetic biology approach to study nucleosome symmetry by creating asymmetric H3 heterodimers and demonstrates their utility in analyzing histone modification crosstalk.

The paper maps H3K9 methylation and other histone modifications in Kluyveromyces lactis, revealing its presence in highly transcribed regions and a disconnect between mark localization and function.