Author

Xi Chen

Harbin Institute of TechnologyORCID 0000-0002-4224-2556Unclaimed ORCID profile · follow to get notified of new preprints

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Xi Chen12 papers · AstraZeneca (United States)

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Chengjian ZhouiD· 1 shared Dinglan WuiD· 1 shared Donglian Wu· 1 shared Ge GaoiD· 1 shared Hao TangiD· 1 shared Huiping HeiD· 1 shared Lei KongiD· 1 shared Ming Chu· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

Chengjian ZhouORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintMar 23, 2025

Identifying Key Cells for Fibrosis by Systematically Calling Cell Type-Phenotype Associations across Massive Heterogenous Datasets

Xi Chen, Yang Ding, Shiqi Yang…·Ge Gao

The paper develops a fibroblast atlas and a toolkit to identify key fibroblast subtypes and their associations with fibrosis, revealing potential therapeutic targets.

DOI 10.1101/2025.03.23.644786

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 27, 2024

Degradation of intrinsically disordered proteins using proteolysis targeting nanobody conjugate

Xiaofeng Sun, Dinglan Wu, Chengjian Zhou…·Xi Chen

This study introduces PROTNC, a system for degrading intrinsically disordered proteins, and demonstrates its effectiveness in targeting TPX2 to inhibit cancer cell proliferation.

2 citations

humanproteomics

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BiochemistrybioRxivPreprintNov 27, 2024

De novo non-compartmentalized microorganism for directed evolution of nanobodies

Donglian Wu, Huiping He, Ruyu Xi…·Xi Chen

This study designs a de novo microorganism, Syn-phage, to evolve nanobodies with improved properties for super-resolution live-cell imaging of endogenous proteins.

DOI 10.1101/2024.11.27.625622

E. coliproteomics

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