Dynamic estimation of metabolic state during CAR T cell production and the relationship of early metabolism to final therapeutic product
Narendra Suhas Jagannathan, Wei‐Xiang Sin, Denise Bei Lin Teo, Faris Kairi, Yen Hoon Luah, Francesca Lim, Michaela Su-Fern Seng, Shui Yen Soh, Yie Hou Lee, Lisa Tucker‐Kellogg, Michael E. Birnbaum, Rajeev J. Ram
This paper develops a modeling framework to estimate T cell metabolic rates during CAR T cell production and shows correlations between early metabolism and final product attributes.
bioRxiv · May 11, 2025 · PreprintCancer Biology