Author

Helen Ibeawuchi

George Washington UniversityORCID 0000-0002-4258-2980Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:eQTL / molecular QTL mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anélia HorvathiD· 4 shared Hongyu LiuiD· 4 shared N. M. PrashantiD· 4 shared Justin Sein· 3 shared Liam Flinn SpurriD· 3 shared Nawaf AlomraniD· 3 shared Pavlos BousounisiD· 3 shared Dacian Reece-Stremtan· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

Anélia HorvathORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Improved SNV discovery in barcode-stratified scRNA-seq alignments

N. M. Prashant, Hongyu Liu, Christian Dillard, Helen Ibeawuchi, Turkey Alsaeedy, Kwan Hang Chan, Anélia Horvath

This study shows that analyzing SNVs from individual cell scRNA-seq alignments identifies more SNVs and reveals functional variants compared to pooled analysis.

Genes · Sep 30, 2021Peer-reviewedGenomics

scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets

Hongyu Liu, N. M. Prashant, Liam Flinn Spurr, Pavlos Bousounis, Nawaf Alomran, Helen Ibeawuchi, Justin Sein, Piotr Słowiński, Krasimira T. Tsaneva-Atanasova, Anélia Horvath

scReQTL correlates SNVs to gene expression in single-cell RNA-seq data by using variant allele fraction instead of population genotypes, enabling analysis of rare variants.

BMC Genomics · Jan 8, 2021Peer-reviewedGenomics

Estimating allele-specific expression of SNVs from 10x Genomics Single-Cell RNA-Sequencing Data

N. M. Prashant, Hongyu Liu, Pavlos Bousounis, Liam Flinn Spurr, Nawaf Alomran, Helen Ibeawuchi, Justin Sein, Dacian Reece-Stremtan, Anélia Horvath

The paper estimates allele-specific expression from 10x Genomics scRNA-seq data and finds that most SNVs are bi-allelic at higher read thresholds, with intronic SNVs showing more monoallelic expression.

Genes · Feb 25, 2020Peer-reviewedGenomics

RsQTL: correlation of expressed SNVs with splicing using RNA-sequencing data

Justin Sein, Liam Flinn Spurr, Pavlos Bousounis, N. M. Prashant, Hongyu Liu, Nawaf Alomran, Jimmy Bernot, Helen Ibeawuchi, Dacian Reece-Stremtan, Anélia Horvath

RsQTL identifies splicing quantitative trait loci by correlating variant allele fractions with splicing patterns in RNA-seq data from human tissues.

bioRxiv · Nov 17, 2019 · PreprintBioinformatics