Author

Justin Sein

George Washington University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 3 Bioinformatics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:eQTL / molecular QTL mapping· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Anélia HorvathiD· 4 shared Liam Flinn SpurriD· 4 shared Nawaf AlomraniD· 4 shared Pavlos BousounisiD· 4 shared Helen IbeawuchiiD· 3 shared Hongyu LiuiD· 3 shared N. M. PrashantiD· 3 shared Dacian Reece-Stremtan· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersGenomics

Anélia HorvathORCID

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Author profile →

5 papers

Recent·Most cited

CIWARS: a web server for waterborne antibiotic resistance surveillance using longitudinal metagenomic data

Muhit Islam Emon, Yat Fei Cheung, James Stoll, Monjura Afrin Rumi, Connor Brown, Joung Min Choi, Nazifa Ahmed Moumi, Shafayat Ahmed, Haoqiu Song, Justin Sein, Shunyu Yao, Ahmad Khan, Suraj Gupta, Rutwik Kulkarni, Ali Raza Butt, , Liqing Zhang

CIWARS is a web server for analyzing longitudinal metagenomic data to detect antibiotic resistance genes and assess AR risks in environmental samples.

bioRxiv · Oct 30, 2024 · PreprintBioinformatics

scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets

Hongyu Liu, N. M. Prashant, Liam Flinn Spurr, Pavlos Bousounis, Nawaf Alomran, Helen Ibeawuchi, Justin Sein, Piotr Słowiński, Krasimira T. Tsaneva-Atanasova, Anélia Horvath

scReQTL correlates SNVs to gene expression in single-cell RNA-seq data by using variant allele fraction instead of population genotypes, enabling analysis of rare variants.

BMC Genomics · Jan 8, 2021Peer-reviewedGenomics

Estimating allele-specific expression of SNVs from 10x Genomics Single-Cell RNA-Sequencing Data

N. M. Prashant, Hongyu Liu, Pavlos Bousounis, Liam Flinn Spurr, Nawaf Alomran, Helen Ibeawuchi, Justin Sein, Dacian Reece-Stremtan, Anélia Horvath

The paper estimates allele-specific expression from 10x Genomics scRNA-seq data and finds that most SNVs are bi-allelic at higher read thresholds, with intronic SNVs showing more monoallelic expression.

Genes · Feb 25, 2020Peer-reviewedGenomics

RsQTL: correlation of expressed SNVs with splicing using RNA-sequencing data

Justin Sein, Liam Flinn Spurr, Pavlos Bousounis, N. M. Prashant, Hongyu Liu, Nawaf Alomran, Jimmy Bernot, Helen Ibeawuchi, Dacian Reece-Stremtan, Anélia Horvath

RsQTL identifies splicing quantitative trait loci by correlating variant allele fractions with splicing patterns in RNA-seq data from human tissues.

bioRxiv · Nov 17, 2019 · PreprintBioinformatics

ReQTL - an allele-level measure of variation-expression genomic relationships

Liam Flinn Spurr, Nawaf Alomran, Piotr Słowiński, Muzi Li, Pavlos Bousounis, Qianqian Zhang, Justin Sein, Keith A. Crandall, Krasimira T. Tsaneva-Atanasova, Anélia Horvath

The paper introduces ReQTL, an eQTL analysis method using RNA genetic variation instead of DNA genotypes, showing high performance in identifying molecular associations from RNA-sequencing data.

bioRxiv · Nov 7, 2018 · PreprintGenomics