Cesar A. Vargas-García

Inference of cell division parameters in bacteria under transient growth conditions

The paper infers cell division parameters in E. coli under nonsteady growth conditions using single-cell size trajectories and time-resolved models.

A Generalized Adder mechanism for Cell Size Homeostasis: Implications for Stochastic Dynamics of Clonal Proliferation

The paper introduces a generalized adder mechanism for cell size homeostasis and shows how it affects clonal proliferation dynamics across different growth laws.

Mechanisms of Cell Size Regulation in Slow-Growing Escherichia coli Cells: Discriminating Models Beyond the Adder

The paper investigates size regulation mechanisms in slow-growing E. coli cells, finding that different models explain size control under varying media conditions.

The role of division stochasticity on the robustness of bacterial size dynamics

This study investigates how stochasticity in bacterial division affects homeostasis, finding that noise in septum position and growth rate dampens oscillations in cell size dynamics.

Cell size regulation and proliferation fluctuations in single-cell derived colonies

The paper develops a framework to model cell size regulation and proliferation dynamics in single-cell-derived colonies, showing that fluctuations in cell number decrease over time in size-dependent models compared to size-independent models.

PyEcoLib: a python library for simulating E. coli stochastic size dynamics

PyEcoLib simulates E. coli stochastic size dynamics by modeling division as a jump process linked to cell size and continuous growth.

Noise signature in added size suggests bacteria target a commitment size to enable division

The paper analyzes bacterial cell size data to show that a commitment size model better explains both mean and fluctuation profiles than degradation-based models.

Cell size statistics in cell lineages and population snapshots with different growth regimes and division strategies.

The paper analyzes how growth regimes and division strategies affect cell-size statistics in bacterial populations using deterministic and stochastic models.

Division stochasticity can be transmitted to protein expression through chromosome replication

This study shows division stochasticity can transmit to protein expression through chromosome replication, but only when replication is occurring.

Stochasticity in bacterial division control: Preliminary consequences for protein concentration

The paper models bacterial cell size dynamics and protein production strategies to predict correlations between protein concentration and cell size.

Joint regulation of growth and division timing drives size homeostasis in proliferating animal cells

The paper uses mathematical models to show that joint regulation of growth and division timing leads to optimal cell size in animal cells by maximizing cellular fitness.

Analysis of noise mechanisms in cell size control

The paper analyzes noise mechanisms in cell size control, showing that volume partitioning errors are most impactful and that timer-adder models lead to power-law size distributions.