Khem Raj Ghusinga

Regulatory strategies to schedule threshold crossing of protein levels at a prescribed time

The paper develops a model to determine optimal regulatory strategies for achieving precise and minimal variability in protein threshold crossing times by analyzing feedback mechanisms and dilution effects.

Molecular switch architecture drives response properties

The paper uses mathematical modeling to compare how different mechanisms of molecular switch activation affect signaling pathway response properties.

Analysis of stochastic timing of intracellular events with gene switching

The paper analyzes how gene switching rates affect the timing distribution of protein threshold crossing in stochastic gene expression models.

Autoregulation of pre-mRNA processing for buffering noisy gene expression

The paper analyzes how different feedback mechanisms affect protein noise levels in gene expression using a stochastic model and identifies optimal strategies under varying conditions.

Noise Analysis in Biochemical Complex Formation

The paper analyzes noise in biochemical complex formation by studying how model parameters affect noise in homomer and heteromer complexes.

Analysis of noise mechanisms in cell size control

The paper analyzes noise mechanisms in cell size control, showing that volume partitioning errors are most impactful and that timer-adder models lead to power-law size distributions.

Controlling noise in the timing of intracellular events: A first-passage time approach

The paper uses a first-passage time framework to analyze how feedback regulation affects the precision of intracellular event timing, finding that constant expression is optimal for stable proteins while positive feedback improves timing for unstable ones.

A mechanistic first-passage time framework for bacterial cell-division timing

The paper develops a first-passage time model to explain bacterial cell-division timing, showing that added volume between divisions is size-independent and noise increases with birth size.