Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases
Jianing Liu, Anokhi Shah, Xinyu Liu, Joshua L. Wort, Yue Ma, Katie Hardman, Niklas G. Johansson, O. M. De Castro Ribeiro, Adam Brookfield, Alice M. Bowen, Jari T. Yli‐Kauhaluoma, Henri Xhaard, Lars J. C. Jeuken, Adrian Goldman, Christos Pliotas, Keni Vidilaseris
This study investigates the inhibitory effects of bisphosphonates on Thermotoga maritima mPPase, revealing conformational asymmetry and symmetry-breaking during catalysis.
eLife · Nov 13, 2025Peer-reviewedBiochemistry