Author

Henri Xhaard

University of HelsinkiORCID 0000-0002-3000-7858Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Adrian GoldmaniD· 3 shared Jari T. Yli‐KauhaluomaiD· 3 shared Keni VidilaserisiD· 3 shared Niklas G. JohanssoniD· 3 shared Jianing LiuiD· 2 shared O. M. De Castro RibeiroiD· 2 shared Adam BrookfieldiD· 1 shared Ainoleena TurkuiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Adrian GoldmanORCID

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Author profile →

3 papers

Recent·Most cited

Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

Jianing Liu, Anokhi Shah, Xinyu Liu, Joshua L. Wort, Yue Ma, Katie Hardman, Niklas G. Johansson, O. M. De Castro Ribeiro, Adam Brookfield, Alice M. Bowen, Jari T. Yli‐Kauhaluoma, Henri Xhaard, Lars J. C. Jeuken, Adrian Goldman, Christos Pliotas, Keni Vidilaseris

This study investigates the inhibitory effects of bisphosphonates on Thermotoga maritima mPPase, revealing conformational asymmetry and symmetry-breaking during catalysis.

eLife · Nov 13, 2025Peer-reviewedBiochemistry

Expression, purification and preliminary pharmacological characterization of the Plasmodium falciparum membrane-bound pyrophosphatase type 1

Jianing Liu, Keni Vidilaseris, Niklas G. Johansson, Orquídea Ribeiro, Loïc Dreano, Jari T. Yli‐Kauhaluoma, Henri Xhaard, Adrian Goldman

This study expresses, purifies, and characterizes the Plasmodium falciparum mPPase, identifying three compounds with micromolar IC50 activity against it.

PLoS ONE · May 27, 2025Peer-reviewedBiochemistry

Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a non-phosphorous allosteric inhibitor

Keni Vidilaseris, Alexandros Kiriazis, Ainoleena Turku, Ayman Khattab, Niklas G. Johansson, Teppo O. Leino, Paula S. Kiuru, Gustav Boije af Gennäs, Seppo Meri, Jari T. Yli‐Kauhaluoma, Henri Xhaard, Adrian Goldman

The paper demonstrates asymmetry in the catalytic cycle of membrane-bound pyrophosphatases using a non-phosphorous allosteric inhibitor bound to Thermotoga maritima enzyme.

Science Advances · May 3, 2019Peer-reviewedMolecular Biology